|
Gene
Regulations
Regulation of gene expression
in heterologous systems; alternative initiation of
translation in bacteria; expression of eukaryotic genes in
bacterial hosts; post-translations modifications of the
recombinant proteins; human cytokines; glycation in bacteria
- structure and function relationship; applied research.
 More Head and staff
Molecular biology of cell cycle
The objective of the
Department is to study the molecular aspects of the
regulation of the cell cycle in higher eukaryotes. We
investigate the mechanisms of activation and repression of
the cell cycle checkpoints in response to DNA damage and the
related processes of DNA repair. A particular focus is given
to the epigenetic changes in DNA and histones that define
the structure of chromatin and their effects on replication,
transcription and recombination of DNA. The aim of our
studies is to find ways to increase sensitivity of cancer
cells to anticancer drugs, as well as ways to deliver the
drugs to the target cells and thus decrease toxcicity of
anticancer therapy, while increasing its efficiency.
More Head and staff
Structure and function of chromatin
HMGB1and 2
proteins as an “architectural” factors of chromatin. Role
in DNA repair. replication and transcription. Influence of
post-synthetic modifications and the C-terminal domain on
the properties of the proteins. Regulation of DNA unwinding
during replication.More Head and staff
Biochemical pharmacology and drug design
Synthesis and mechanism
of action of analogs of pyrimidines, purines, amino acids
and neuropeptides, platinum complexis and other antitumor
agents. Natural and synthetic inhibition of
UDP-glucuronosyltransferase. Microbial diversity and
activity in polluted anvironments.
More Head and staff
Laboratory of Yeast Molecular Genetics
The main aim of the
Laboratory Of Yeast Molecular Genetics is centered on
molecular biology and genetics of yeasts. However, the
research is performed not only on yeast cells but also
includes mammalian culture cells and laboratory animals
(mice and rats).
More Head and staff
Bioactive peptides
Laboratory for Medical and Biological Research
Development of cutting-edge research programs to address significant physiological and pathophysiological mechanisms and maintenance of an active linkage between basic and clinical investigators with research programs in atherosclerosis, cardiovascular biology, diabetes, cancer and
nanotechnology. More Head and staff
|
