Name

Boyka Borissova Anchkova

 

 

Selected publications:

1.         Koprinarova, M., P. Markovska, I. Iliev, B. Anachkova, and G. Russev, Sodium butyrate enhances the cytotoxic effect of cisplatin by abrogating the cisplatin imposed cell cycle arrest. BMC Mol Biol, 2010. 11: p. 49.

2.         Gospodinov, A. and B. Anachkova, Lack of effect of RuvB-like proteins on DNA damage signaling activation. Z Naturforsch C, 2010. 65(1-2): p. 148-52.

3.         Mladenov, E., P. Kalev, and B. Anachkova, The complexity of double-strand break ends is a factor in the repair pathway choice. Radiat Res, 2009. 171(4): p. 397-404.

4.         Mladenov, E.V., P.S. Kalev, and B.B. Anachkova, Nuclear matrix binding site in the Rad51 recombinase. J Cell Physiol, 2009. 219(1): p. 202-8.

5.         Gospodinov, A., I. Tsaneva, and B. Anachkova, RAD51 foci formation in response to DNA damage is modulated by TIP49. Int J Biochem Cell Biol, 2009. 41(4): p. 925-33.

6.         Mladenov, E., I. Tsaneva, and B. Anachkova, Cell cycle-dependent association of Rad51 with the nuclear matrix. DNA Cell Biol, 2007. 26(1): p. 36-43.

7.         Mladenov, E., I. Tsaneva, and B. Anachkova, Activation of the S phase DNA damage checkpoint by mitomycin C. J Cell Physiol, 2007. 211(2): p. 468-76.

8.         Mladenov, E., B. Anachkova, and I. Tsaneva, Sub-nuclear localization of Rad51 in response to DNA damage. Genes Cells, 2006. 11(5): p. 513-24.

9.         Anachkova, B., V. Djeliova, and G. Russev, Nuclear matrix support of DNA replication. J Cell Biochem, 2005. 96(5): p. 951-61.

10.       Atanassov, B., A. Gospodinov, I. Stoimenov, E. Mladenov, G. Russev, I. Tsaneva, and B. Anachkova, Repair of DNA interstrand crosslinks may take place at the nuclear matrix. J Cell Biochem, 2005. 96(1): p. 126-36.

11.       Radichev, I., A. Parashkevova, and B. Anachkova, Initiation of DNA replication at a nuclear matrix-attached chromatin fraction. J Cell Physiol, 2005. 203(1): p. 71-7.

12.       Gospodinov, A., R. Ivanov, B. Anachkova, and G. Russev, Nucleotide excision repair rates in rat tissues. Eur J Biochem, 2003. 270(5): p. 1000-5.

13.       Djeliova, V., G. Russev, and B. Anachkova, DNase I sensitive site in the core region of the human beta-globin origin of replication. J Cell Biochem, 2002. 87(3): p. 279-83.

14.       Djeliova, V., G. Russev, and B. Anachkova, Dynamics of association of origins of DNA replication with the nuclear matrix during the cell cycle. Nucleic Acids Res, 2001. 29(15): p. 3181-7.

15.       Djeliova, V., G. Russev, and B. Anachkova, Distribution of DNA replication origins between matrix-attached and loop DNA in mammalian cells. J Cell Biochem, 2001. 80(3): p. 353-9.

16.       Mikhailov, I., P. Ninova, G. Russev, and B. Anachkova, Iron(II)-mimosine catalyzed cleavage of DNA. Z Naturforsch C, 2000. 55(9-10): p. 849-51.

17.       Kunnev, D., A. Gospodinov, G. Russev, and B. Anachkova, Regulation of DNA synthesis by the higher-order chromatin structure. DNA Cell Biol, 2000. 19(5): p. 283-90.

18.       Mikhailov, I., G. Russev, and B. Anachkova, Treatment of mammalian cells with mimosine generates DNA breaks. Mutat Res, 2000. 459(4): p. 299-306.

19.       Kunnev, D., L. Tsvetkov, B. Anachkova, and G. Russev, Clusters of replicons that fire simultaneously may be organized into superloops. DNA Cell Biol, 1997. 16(9): p. 1059-65.

20.       Tsvetkov, L.M., G.C. Russev, and B.B. Anachkova, Effect of mimosine on DNA synthesis in mammalian cells. Cancer Res, 1997. 57(11): p. 2252-5.

21.       Gencheva, M., B. Anachkova, and G. Russev, Mapping the sites of initiation of DNA replication in rat and human rRNA genes. J Biol Chem, 1996. 271(5): p. 2608-14.

22.       Gencheva, M. and B. Anachkova, Clusters of modular regulatory elements at DNA replication origins. Gene, 1995. 164(2): p. 283-7.

23.       Dimitrova, D., L. Vassilev, B. Anachkova, and G. Russev, Isolation and cloning of putative mouse DNA replication initiation sites: binding to nuclear protein factors. Nucleic Acids Res, 1993. 21(24): p. 5554-60.

24.       Lallev, A., B. Anachkova, and G. Russev, Effect of ionizing radiation and topoisomerase II inhibitors on DNA synthesis in mammalian cells. Eur J Biochem, 1993. 216(1): p. 177-81.

25.       Anachkova, B. and J.L. Hamlin, Replication in the amplified dihydrofolate reductase domain in CHO cells may initiate at two distinct sites, one of which is a repetitive sequence element. Mol Cell Biol, 1989. 9(2): p. 532-40.

26.       Anachkova, B., G. Russev, and H. Altmann, Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements. Biochem Biophys Res Commun, 1985. 128(1): p. 101-6.

27.       Anachkova, B., M. Todorova, L. Vassilev, and G. Russev, Isolation of short interspersed repetitive DNA sequences present in the regions of initiation of mammalian DNA replication. Eur J Biochem, 1984. 141(1): p. 105-8.

28.       Anachkova, B. and G. Russev, Evidence for the existence of a fraction of rat liver chromatin containing only a few specific nonhistone proteins and reduced amount of histone H1. FEBS Lett, 1977. 81(1): p. 37-8.

 

 

Positions

 

1999 – till now - Full professor in Institute of Molecular Biology

1997 – till now - Head of department “Molecular biology of the cell cycle” in Institute of Molecular Biology

 

Grant awards

 

Grant No: Ê-205/92, financed by the National Science Fund

Grant No: Ê-604/96, financed by the National Science Fund

Grant No: G1-02/03, financed by the National Science Fund

Grant No: CIPA-CT93-0135, financed by the European Commission

Grant No: 070397/Z/03/Z, financed by the Wellcome Trust, UK

 

Scientific awards

1995 – The award of the Bulgarian National Science Fund in molecular biology

1998 - The award of the Bulgarian Academy of Sciences in biology

 

 

Postgraduate students

 

7 Ph.D. students

10 Master degree students

 

Research Interests

 

Author of over 50 publications in the following fields:

Structure and function of chromatin

DNA replication

Cell cycle

DNA repair

The papers have been cited over 260 times


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