George Christov Russev            

Selected publications:                            

1.         Koprinarova, M., P. Markovska, I. Iliev, B. Anachkova, and G. Russev, Sodium butyrate enhances the cytotoxic effect of cisplatin by abrogating the cisplatin imposed cell cycle arrest. BMC Mol Biol, 2010. 11: p. 49.

2.         D'Auria, S., L. Petrova, C. John, G. Russev, A. Varriale, and V. Bogoeva, Tumor-specific protein human galectin-1 interacts with anticancer agents. Mol Biosyst, 2009. 5(11): p. 1331-6.

3.         Bogoeva, V.P. and G.C. Russev, Fluorescence study of steroid hormone binding activity of Helix pomatia agglutinin. Steroids, 2008. 73(11): p. 1060-5.

4.         Koprinarova, M. and G. Russev, Histone H4 acetylation during UV light induced G1 and S phase arrest of the cell cycle. Cell Cycle, 2008. 7(10): p. 1496-8.

5.         Koprinarova, M.A. and G.C. Russev, Dynamics of histone H4 acetylation during the cell cycle. Cell Cycle, 2008. 7(3): p. 414-6.

6.         Mladenova, V. and G. Russev, Enhanced repair of DNA interstrand crosslinks in S phase. FEBS Lett, 2006. 580(6): p. 1631-4.

7.         Anachkova, B., V. Djeliova, and G. Russev, Nuclear matrix support of DNA replication. J Cell Biochem, 2005. 96(5): p. 951-61.

8.         Atanassov, B., A. Gospodinov, I. Stoimenov, E. Mladenov, G. Russev, I. Tsaneva, and B. Anachkova, Repair of DNA interstrand crosslinks may take place at the nuclear matrix. J Cell Biochem, 2005. 96(1): p. 126-36.

9.         Gospodinov, A., G. Russev, and B. Anachkova, Determination of DNA repair capacity of protein extracts by restoration of the transformation efficiency of damaged plasmids. Anal Biochem, 2003. 315(2): p. 285-8.

10.       Gospodinov, A., R. Ivanov, B. Anachkova, and G. Russev, Nucleotide excision repair rates in rat tissues. Eur J Biochem, 2003. 270(5): p. 1000-5.

11.       Atanassov, B.S., P.D. Ninova, B.B. Anachkova, and G.C. Russev, Relationship between DNA repair capacity and resistance to genotoxins in four human cell lines. Cancer Detect Prev, 2003. 27(1): p. 24-9.

12.       Djeliova, V., G. Russev, and B. Anachkova, DNase I sensitive site in the core region of the human beta-globin origin of replication. J Cell Biochem, 2002. 87(3): p. 279-83.

13.       Djeliova, V., G. Russev, and B. Anachkova, Dynamics of association of origins of DNA replication with the nuclear matrix during the cell cycle. Nucleic Acids Res, 2001. 29(15): p. 3181-7.

14.       Djeliova, V., G. Russev, and B. Anachkova, Distribution of DNA replication origins between matrix-attached and loop DNA in mammalian cells. J Cell Biochem, 2001. 80(3): p. 353-9.

15.       Roguev, A. and G. Russev, Two-wavelength fluorescence assay for DNA repair. Anal Biochem, 2000. 287(2): p. 313-8.

16.       Kunnev, D., A. Gospodinov, G. Russev, and B. Anachkova, Regulation of DNA synthesis by the higher-order chromatin structure. DNA Cell Biol, 2000. 19(5): p. 283-90.

17.       Mikhailov, I., G. Russev, and B. Anachkova, Treatment of mammalian cells with mimosine generates DNA breaks. Mutat Res, 2000. 459(4): p. 299-306.

18.       Chakalova, L. and G. Russev, Transcriptionally active and inactive mouse beta-globin gene loci are repaired at similar rates after ultraviolet irradiation. Eur J Biochem, 1999. 261(3): p. 667-73.

19.       Chakalova, L. and G. Russev, Comparison of repair activity in different genomic regions. Acta Biochim Pol, 1998. 45(1): p. 173-81.

20.       Chakalova, L. and G. Russev, Quantitative polymerase chain reaction assay for DNA repair within defined genomic regions. Mutat Res, 1998. 407(2): p. 147-55.

21.       Kunnev, D., L. Tsvetkov, B. Anachkova, and G. Russev, Clusters of replicons that fire simultaneously may be organized into superloops. DNA Cell Biol, 1997. 16(9): p. 1059-65.

22.       Chakarov, S., P. Stoilov, A. Alexandrov, and G. Russev, Repair pattern in the beta-globin gene cluster of human fibroblasts after ultraviolet irradiation. Eur J Biochem, 1997. 248(3): p. 669-75.

23.       Tsvetkov, L.M., G.C. Russev, and B.B. Anachkova, Effect of mimosine on DNA synthesis in mammalian cells. Cancer Res, 1997. 57(11): p. 2252-5.

24.       Tsvetkov, L. and G. Russev, Decreased rates of replicon initiation in mammalian cells. Eur J Biochem, 1996. 237(2): p. 489-95.

25.       Dimitrova, D., L. Vassilev, B. Anachkova, and G. Russev, Isolation and cloning of putative mouse DNA replication initiation sites: binding to nuclear protein factors. Nucleic Acids Res, 1993. 21(24): p. 5554-60.

26.       Russev, G. and T. Boulikas, Repair of transcriptionally active and inactive genes during S and G2 phases of the cell cycle. Eur J Biochem, 1992. 204(1): p. 267-72.

27.       Anachkova, B., G. Russev, and G.G. Poirier, DNA replication and poly(ADP-ribosyl)ation of chromatin. Cytobios, 1989. 58(236): p. 19-28.

28.       Vassilev, L. and G. Russev, Purification of nascent DNA chains by immunoprecipitation with anti-BrdU antibodies. Nucleic Acids Res, 1988. 16(21): p. 10397.

29.       Vassilev, L. and G. Russev, Kinetics of replicon initiation during S phase of Chinese hamster ovary cells. Biochim Biophys Acta, 1988. 949(1): p. 138-42.

30.       Pironcheva, G., N. Zhelev, and G. Russev, Isolation of U5 snRNP particles. Cytobios, 1988. 56(224): p. 39-44.

31.       Vassilev, L. and G. Russev, Distribution of the short dispersed repetitive sequences B1 and B2 in the mouse genome. Int J Biochem, 1986. 18(11): p. 1069-71.

32.       Anachkova, B., G. Russev, and H. Altmann, Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements. Biochem Biophys Res Commun, 1985. 128(1): p. 101-6.

33.       Todorova, M. and G. Russev, Random distribution of mammalian replication origins in matrix and total nuclear DNA. Biochim Biophys Acta, 1984. 783(1): p. 36-41.

34.       Anachkova, B., M. Todorova, L. Vassilev, and G. Russev, Isolation of short interspersed repetitive DNA sequences present in the regions of initiation of mammalian DNA replication. Eur J Biochem, 1984. 141(1): p. 105-8.

35.       Vassilev, L. and G. Russev, Hydroxyurea treatment does not prevent initiation of DNA synthesis in Ehrlich ascites tumour cells and leads to the accumulation of short DNA fragments containing the replication origins. Biochim Biophys Acta, 1984. 781(1-2): p. 39-44.

36.       Anachkova, B. and G. Russev, Differential binding of nonhistone chromosomal proteins to the putative mouse origin of replication. Biochim Biophys Acta, 1983. 740(4): p. 369-72.

37.       Anachkova, B. and G. Russev, Labelling pattern of the nonhistone chromosomal proteins in quiescent and dividing Ehrlich ascites tumour cells. Int J Biochem, 1983. 15(8): p. 1093-4.

38.       Pospelov, V., B. Anachkova, and G. Russev, Organization of the newly replicated chromatin in the vicinity of the replication fork. Biochim Biophys Acta, 1982. 699(3): p. 241-6.

39.       Russev, G. and L. Vassilev, Isolation of a DNA fraction from Ehrlich ascites tumour cells containing the putative origin of replication. J Mol Biol, 1982. 161(1): p. 77-87.

40.       Russev, G. and R. Hancock, Assembly of new histones into nucleosomes and their distribution in replicating chromatin. Proc Natl Acad Sci U S A, 1982. 79(10): p. 3143-7.

41.       Pospelov, V., G. Russev, L. Vassilev, and R. Tsanev, Nucleosome segregation in chromatin replicated in the presence of cycloheximide. J Mol Biol, 1982. 156(1): p. 79-91.

42.       Russev, G. and R. Hancock, Formation of hybrid nucleosomes cantaining new and old histones. Nucleic Acids Res, 1981. 9(16): p. 4129-37.

43.       Vassilev, L., G. Russev, and R. Tsanev, Heterogeneity of nucleosomes upon dissociation with salts. Int J Biochem, 1981. 13(12): p. 1247-55.

44.       Russev, G., L. Vassilev, and R. Tsanev, Histone exchange in chromatin of hydroxyurea-blocked Ehrlich ascites tumour cells. Nature, 1980. 285(5766): p. 584-6.

45.       Russev, G. and R. Tsanev, Nonrandom segregation of histones during chromatin replication. Eur J Biochem, 1979. 93(1): p. 123-8.

46.       Anachkova, B. and G. Russev, Evidence for the existence of a fraction of rat liver chromatin containing only a few specific nonhistone proteins and reduced amount of histone H1. FEBS Lett, 1977. 81(1): p. 37-8.

DEGREES:                                             

1965, M.S. in chemistry from University of Sofia "St. Kl. Ohridski"

1971, Ph.D. in biology from Institute of  Molecular Biology, BAS

1981, D.Sc. from The Higher Evaluation Commission, Bulgaria

1995, Full Member of Bulgarian National  Academy of Medicine

2004, Corresponding member of the Bulgarian Academy of Sciences

POSITIONS HELD:

1974-1978, Research assistant professor, Department of

Biochemistry, Faculty of Medicine, Higher Medical Institute, Sofia

1978-1984, Research associate professor

1984-present, Head of Laboratory

1984-present, Full research professor

1989-1997, Head of Department

1993-2003, Director of IMB

2004-present, corresponding member of BAS

All positions since 1978 are held at the Institute of  Molecular 

Biology, Bulgarian Academy of Sciences, Sofia

COMMITTEES:

1985-present, National Specialised Scientific Council (The national

scientific degrees giving body in the fields of molecular biology,

biochemistry, biophysics and genetics)

1992-1993, Chairman of the National Specialised Scientific

Council.

1992-1993, Executive Council of the Bulgarian Academy of

 Sciences

1993-1995, National Higher Evaluation Commission (government)

1993-2003,  Board of Directors of National Science Fund (National

 grant giving body)

1995-2003, Member of the General Assembly of BAS

INTERNATIONAL COLLABORATION:

Extensive with groups  in USSR, Western Europe and USA

working on different  aspects of DNA repair, DNA replication,

chromatin structure and cancerogenesis.       

1980, Visiting professor in ISREC, Losanna, Switzerland

for 6 months

1985, Visiting professor in Oncological Center Hotel Dieu

de Quebec, Quebec city, Canada for 4 months

1988, Visiting professor in Roswell Park Cancer Institute, Buffalo,

USA for 4 months

1990-1992, Visiting professor in Linus Pauling Institute of Science

and Medicine, Palo Alto USA  for 2 years

1994, Visiting professor in the University of Konstanz, Germany for

3 months.

1995, Visiting professor in Oncological Center Hotel Dieu

de Quebec, Quebec city, Canada for 4 months

LECTURING:

Invited lecturer at international symposiums and congresses

and in many universities and scientific institutes in Europe and

North America.

PAPERS:

Over 120 scientific papers and several invited reviews

in national and international scientific journals. They were cited

over 700 times including in world-wide known textbooks

such as Molecular Biology of the Cell by Alberts et al,

 Molecular Cell Biology by Darnell et  all,  DNA Replication

 by Kornberg and  Baker, etc.

TEACHING:

1974-1978, practical course of biochemistry, Department of

Biochemistry, Medical Faculty, Sofia

1993-present, graduate course on Recombinant DNA in

Biological Faculty of University of Sofia

1978-present, over 30 M.Sc. and Ph.D. students